Essay (40%): word limit 2,000 words excluding bibliographic reference list and figure legends Submission deadline 14th December 4pm. 6BBB0345 Genetics of Model Organisms 2020/21 Title: Nematode worm and fruit fly models of Alzheimers disease: how Caenorhabditis elegans and Drosophila melanogaster have been used to progress our understanding of factors that control toxicity associated with aggregated protein. • There is a considerable body of research on Alzheimers, which exploits use of the nematode worm (Caenorhabditis elegans) and Drosophila model systems o Bear in mind you are not expected to cover every single facet of Alzheimers disease. Two students could write very different essays and score the same grade • Higher scoring essays will be ones that take a more comprehensive approach in answering this question o e.g. grade will be limited if you only focus on the outcome of using one technique or discuss only one relevant cellular pathway. A coherent essay will discuss the nematode worm and Drosophila models in two separate sections. Incorporation of relevant diagrams, that are cited in the text, is a feature common to high scoring essays Remember to cite the source of a diagram or figure at the end of the legend. Include the reference in your bibliographic list at the end of the essay. You can include images from primary data (remembering to cite the sources). If you paste-in a diagram or an image of primary data, you must include a legend. Don’t copy the text of the legend from the article directly into your essay (this would count as plagiarism). Re-write the image in your own words. Make sure you define all the symbols featured in the figure. Don’t paste it in as an image, this would look like an attempt to escape detection of plagiarism by turnitin. A high scoring essay will also include some text that compares use of the nematode worm and Drosophila models e.g. disadvantages and advantages for each model or, are there techniques that have been applied in one model that could not (or have not) been applied to the other model? You could include this type of comparative text as you go along or present it as a separate section (would have to be fairly lengthy, not just a short paragraph at the end of the essay). You are expected to cite around twenty references, of these upto five can be reviews but the rest have to be primary research articles You will drop marks if you do not apply the same citation and listing style throughout e.g. in your reference list, journal titles should be written in the same format i.e. you can give abbreviated titles like ‘PNAS USA’ or non-abbreviated titles, like ‘Proceedings of the Natural Academy of Sciences USA’. You should not use both styles (i.e. abbreviating some journal titles, but giving full titles for others). A quick guide to the School's two most commonly used referencing styles can be found here: http://libguides.kcl.ac.uk/ld.php?content_id=14064072 Given the amount of literature you will find when you search for relevant information, it is recommended that you look at reviews first. If your searches identify large numbers of references, try refining the search e.g. if you use the term ‘Alzheimers and Drosophila’ or ‘Alzheimers and elegans’ under the ‘title’ setting in Web of knowledge, you will pick up hundreds of hits. If you then select the reviews only (check the ’review’ box under ‘document type’ then click ‘refine’), you will reduce this to a much more manageable number of hits (you can look at all the titles and abstracts of these, then select the ones to read). During the literature searches, use wild-cards to make sure you don’t miss key studies e.g. some articles may have Alzheimers or Alzheimer’s or Alzheimers-related in the title. To catch all of these, use ‘Alzheimer*’ (this works in Web of Science).
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