程序代写案例-MATH97075 MATH97183
© 2020 Imperial College London Page 1 MATH97075 MATH97183 BSc, MSci and MSc EXAMINATIONS (MATHEMATICS) May-June 2020 This paper is also taken for the relevant examination for the Associateship of the Royal College of Science Survival Models and Actuarial Applications SUBMIT YOUR ANSWERS AS ONE PDF TO THE RELEVANT DROPBOX ON BLACKBOARD INCLUDING A COMPLETED COVERSHEET WITH YOUR CID NUMBER, QUESTION NUMBERS ANSWERED AND PAGE NUMBERS PER QUESTION. . Date: 11th May 2020 Time: 09.00am - 11.30am (BST) Time Allowed: 2 Hours 30 Minutes Upload Time Allowed: 30 Minutes This paper has 5 Questions. Candidates should start their solutions to each question on a new sheet of paper. Each sheet of paper should have your CID, Question Number and Page Number on the top. Only use 1 side of the paper. Allow margins for marking. Any required additional material(s) will be provided. Credit will be given for all questions attempted. Each question carries equal weight. 1. (a) State the Kaplan-Meier Estimator, Sˆ(t), of the survivor function S(t) and the Nelson-Aalen Estimator, Mˆ(t), of the cumulative hazard function M(t). Clearly define all quantities appearing in the estimators. (5 marks) (b) Give 3 equivalent expressions that can be useful in different contexts for the hazard rate µ(t) of a continuous random variable T . (3 marks) (c) Derive Greenwood’s estimator of the standard error of Sˆ(t), s.e.{Sˆ(t)}. (5 marks) (d) Pointwise (1−α)-confidence intervals for S(t) can be constructed based on the approximate distribution Sˆ(t) ∼ N ( S(t), s.e.{Sˆ(t)}2 ) . However, the resulting intervals may include negative values for S(t). Derive an estimator of the standard error of log Sˆ(t). Using a normal approximation, explain how to construct a non-negative, asymptotically valid (1−α)-confidence interval for S(t) based on your estimate of s.e.[log Sˆ(t)]. (3 marks) (e) Construct an alternative non-parametric estimator of the survivor function, S˜(t), based on ∗ the Nelson-Aalen estimator Mˆ(t); and ∗ the relationship between the survivor function and cumulative hazard rate. Show that Sˆ(t) ≤ S˜(t) for all t ≥ 0. (4 marks) (Total: 20 marks) MATH96048/MATH97075/MATH97183 Survival Models and Actuarial Applications (2020) Page 2 2. Consider the proportional hazards model µ(t; z) = µ0(t) exp(zβ) for z, β ∈ R. (a) State the partial likelihood L(β) for this model based on a random sample where some observations are subject to right-censoring in two cases: (i) all death times are distinct, (ii) accounting for ties using the Breslow approximation. (5 marks) (b) Define the likelihood ratio test statistic Λ of the hypothesis H0 : β = 0 against H1 : β 6= 0. What is the asymptotic distribution of the statistic? (3 marks) (c) Consider the following dataset arising from the proportional hazards model: i tobs,i zi 1 1.1 1 2 1.3+ 0 3 1.4 1 4 1.4 0 5 1.6+ 0 6 2.3 1 Write down and simplify the partial likelihood for these data. (5 marks) (d) It is known that U(β) := ∂ ∂β logL(β) has an approximate N(0, I(β)) distribution. Show that when z ∈ {0, 1} U(0) = k∑ j=1 ( d1j − dj n1j nj ) and I(0) = k∑ j=1 n1jn0jdj n2j where t1 < . . . < tk denote the distinct death times, dij denotes the number of deaths with z = i at time tj, nij denotes the number of individuals at risk with z = i just before tj, and nj = n1j + n0j, dj = d1j + d0j. (4 marks) (e) Define an approximate level α test of the hypothesis H0 : β = 0 against H1 : β 6= 0 based on the statistic U(0) from part (d). Briefly explain which single quantity from ∑kj=1 nj, ∑kj=1 dj and ∑kj=1(nj + dj) has most effect on the appropriateness of the approximation. (3 marks) (Total: 20 marks) MATH96048/MATH97075/MATH97183 Survival Models and Actuarial Applications (2020) Page 3 3. The Binomial model of mortality is used to model the number of deaths before age x + 1 in a sample of n individuals still alive at the exact integer age x, with independent probability of death qx ≡ 1qx for each individual. Individual i is assumed to be available for observation only within a sub-interval [x + ai, x + bi), for 0 ≤ ai < bi ≤ 1, with corresponding death probability bi−aiqx+ai during this observation period. Let di = 0, 1 be equal to 1 if individual i within the age group [x, x+ 1) died, and let d = ∑ni=1 di be the total number of deaths. (a) The Initial Exposed to Risk is Ex := ∑n i=1(1− ai)− ∑n i=1(1− di)(1− bi). (i) Compare the contribution to Ex of individual i that is censored or uncensored. (2 marks) (ii) Express the Central Exposed to Risk, Ecx, in terms of the ai, bi and di. (2 marks) (iii) Derive the formula Ex ≈ Ecx + 12d. Clearly state all required assumptions. (4 marks) (b) An entomologist is studying the lifespan of a particular species of dragonfly that has a maximum lifespan of ω ≈ 4 months. They have obtained the Central Exposed to Risk at age x and number of deaths in the interval [x, x + 1) from a sample of dragonflies for x = 0, 1, 2, 3, where x is the age of a dragonfly in months. Estimate qx for x = 0, 1, 2, 3 from this data: x Ecx d 0 35 10 1 45 6 2 75 30 3 60 40 (5 marks) (c) From the data in part (b), estimate the curtate expectation of life for a dragonfly currently aged x = 1 months. That is, estimate e1. (3 marks) (d) In part (b), estimates of qx are obtained separately for each interval [x, x + 1). In reality, it is believed that qx is a smooth function of x. The process of smoothing crude actuarial estimates is called graduation, and results in graduated estimates. By smoothing the estimates of qx from part (b), the entomologist obtains graduated estimates q˚0 = 0.2, q˚1 = 0.2, q˚2 = 0.3, and q˚3 = 0.5 Using the data in part (b), conduct a cumulative deviations test at the α = 0.05 level, using the graduated values to define the null hypothesis, and simplifying the test statistic as much as possible. Note that P (|X| > 1.96) ≈ 0.05 for X ∼ N(0, 1). (4 marks) (Total: 20 marks) MATH96048/MATH97075/MATH97183 Survival Models and Actuarial Applications (2020) Page 4 4. The following diagram illustrates the resulting 3-state model for a homogeneous Markov jump process X(t) denoting the status of a given patient receiving a bone marrow transplant: Transplant0 Platelet recovery2 Relapse or death1 - µ02 @ @ @ @ @ @ @ @ @ @R µ01 µ21